Clinical Laboratory Diagnosis №6 2008

Rakhmanina O. A., Levitina Ye. V., Zhuravleva T. D.

Calcium homeostasis and nitric oxide processes in children with migraine

Eighty-one children aged 6 to 17 years who had migraine were examined by clinical and biochemical studies. The activity of Ca2+-ATP ase and the levels of total intracellular calcium of platelets and plasma nitrites were studied in the attack-free period. Children with migraine were fond to have elevated levels of stable nitric oxide metabolites (nitrites). The level of intracellular calcium was 2 times greater than that in healthy children of the same age, which was followed by compensatory Ca2+-ATPase activation. There was a relationship of the parameters of calcium homeostasis and the plasma level of nitrites to the clinical and pathogenetic manifestations of migraine.