Clinical Laboratory Diagnosis №6 2008

Afanasyeva A. N., Tuzikov S. A., Yevtushenko V. A., Udut V. V.

Platelet functional status in patients with gastric cancer at combined treatment stages 

Platelets are active cells that excrete various humoral factors that contribute to thrombogenesis and inflammation. The investigation was undertaken to study induced platelet aggregation in patients with gastric cancer at combined treatment stages and to evaluate the impact of intraoperative radiotherapy (IOR). The study covered patients with gastric cancer (GC). Group 1 included Stage III GC patients who had undergone elective radical surgery; Group 2 comprised Stage III GC patients who had radical surgery with a session of IOR; Group 3 consisted of Stage IV GC patients who had undergone palliative surgery or explorative laparotomy. Induced platelet aggregation were explored from the BIOLA aggregometer (Russia) readings before, 30 minutes, 1, 3, 5, 7, and 14 days after surgery. Adenosine phosphate, adrenaline, collagen were used as inducers. It is concluded that there is a need for postoperative laboratory control and correction of platelet activity. In GC patients operated on with IOR, platelet activity should be monitored for at least 2 weeks after surgery.